Great ingredients to boost your overall health profile oncycle or anytime.

Here are a few ingredients that can help you on cycle or off to maintain a better health profile.

1. Coq10- CoQ10 is sometimes hailed as a natural “wonder drug” as it has so many positive effects, including well-documented effects on the heart, blood pressure, and fertility. Studies also show reduced fatigue and enhanced peak power in athletes.

2. Hawthorne Berry-  Hawthorne is highly recognized as a superstar herb for the heart and cardiovascular system. It has the ability to dilate (enlarge or open) the coronary arteries (the vessels that supply blood to the heart), thus improving blood and oxygen supply to the heart muscle. It also strengthens the hearts pumping ability (muscle), helping the heart to beat more forcefully and efficiently.

3. Sam e.- S-adenosylmethionine is an endogenous methyl group donor and precursor to glutathione, which may be able to prevent androgen-induced cholestasis and liver injury. SAMe can inhibit bile acid-induced hepatocyte apoptosis, [10][11][12] downregulates expression of the inflammatory cytokine TNF-alpha, [13][14] and can reduce oxidative stress via glutathione replenishment, [15] which may also play a role in ameliorating the effects of cholestasis. [16] SAMe has been studied extensively as a safe and effective treatment for pregnancy-induced cholestasis, [17][18][19] and, in a case study, was even shown to reverse severe androgen-induced cholestasis. [20] Due to its distinct mechanism of action, it has an additive effect when used alongside UDCA/TUDCA. [10][18]

4. Tudca-  Tauroursodeoxycholic acid: Can prevent apoptosis during cholestasis. Toxic bile acids produce apoptosis Via fas- and TRAIL- death receptor mediated pathways. Both are, to some degree, dependent on the translocation of the 'bax' pro-apoptoic molecule from the cytosol of hepatocytes to the cell mitochondria. TUDCA prevents bax translocation, strongly stabilizes mitochondrial membranes, and activates the MAPK pro-survival pathway in hepatocytes. (1) These effects protect hepatocytes from bax-related apoptosis.
-Is a hydrophilic bile acid, and its presence markedly shifts the bile pool towards hydrophilicity, which, to some extent, detoxifies it. When used consistently, especially at pharmacological doses, TUDCA (along with UDCA) eventually becomes the predominant bile acid in the liver and in general circulation. (2)
-Directly stimulates bile secretion via modulating cellular signalling pathways in hepatocytes, such as ERK, src, PKC and others. These signalling pathways generally phosphorylate, or activate, the bile salt export pump (BSEP) and other processes involved in bile export/secretion. (For example, PKC-alpha-mediated secretion of HCO3-.) (3, 4, 5)